Enhancing bone marrow regeneration by SALL4 protein
نویسندگان
چکیده
منابع مشابه
Enhancing bone marrow regeneration by SALL4 protein
Hematopoietic stem cells (HSCs) are widely used in transplantation therapy to treat a variety of blood diseases. The success of hematopoietic recovery is of high importance and closely related to the patient's morbidity and mortality after Hematopoietic stem cell transplantation (HSCT). We have previously shown that SALL4 is a potent stimulator for the expansion of human hematopoietic stem/prog...
متن کاملSecreted Frizzled-Related Protein Promotes Bone Regeneration by Human Bone Marrow-Derived Mesenchymal Stem Cells
Secreted frizzled-related protein (sFRP)-3 is a negative regulator of Wnt signaling in human mesenchymal stem cells (hMSCs). The present study investigated the effects sFRP-3 on osteogenic differentiation by assessing osteogenic gene expression in hMSCs in vitro and by examining bone regeneration in a rat bone defect model. sFRP-3 treatment induced osteogenic differentiation in hMSCs as determi...
متن کاملMyocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration.
The primary cardiac response to ischemic insult is cardiomyocyte hypertrophy, which initiates a genetic program culminating in apoptotic myocyte loss, progressive collagen replacement, and heart failure, a process termed cardiac remodeling. Although a few cardiomyocytes at the peri-infarct region can proliferate and regenerate after injury, no approaches are known to effectively induce endogeno...
متن کاملBone regeneration post-bone marrow necrosis mimicking hyperparathyroid bone disease
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 47-year-old woman visited our hospital complaining of recently developed back pain. Complete blood cell counts cells. Her bone marrow (A) (H&E, ×400) was packed with blasts, which were positive for CD34, CD19, CD20, CD10, and TdT. The diagnosis of precurso...
متن کاملBone marrow regeneration in experimental benzene intoxication.
By BERNHARD STEINBERG, M.D. B ENZENE intoxication is known to affect the hemopoietic system of man and of lower animals. Depending upon the duration of exposure, concentration of the chemical, frequency of administration and the age of the animal, changes of the bone marrow vary from complete aplasia to selective hypoplasia. Since little is known of the regulating mechanism of production and di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2013
ISSN: 1756-8722
DOI: 10.1186/1756-8722-6-84